Polycephalums A and B, New Anticoagulant Constituents Isolated from <i>Clinopodium polycephalum</i>-Reference-Cited by-同舟云学术

Polycephalums A and B, New Anticoagulant Constituents Isolated from Clinopodium polycephalum

Published:2023-06 Issue:6 Volume:20 Page:
ISSN:1612-1872
Container-title:Chemistry & Biodiversity
language:en
Short-container-title:Chemistry & Biodiversity

Author:

Tao Muke¹²,Liu Yaxuan³,Zhou Xiangmin²,Yu Xinlan⁴,Zhang Yi²,Guo Li¹,Meng Dali³^ORCID

Affiliation:

1. State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu 611137 P. R. China

2. Chongqing Institute for Food and Drug Control NMPA Key Laboratory for Quality Monitoring of Narcotic Drugs and Psychotropic Substances Chongqing 401121 P. R. China

3. School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 P. R. China

4. Xinjiang Institute for Drug Control Urumqi 830004 P. R. China

Abstract

AbstractTwo previously undescribed compounds (1 and 2) were isolated from Clinopodium polycephalum, a medicinal plant distributed in southwestern and eastern China. Their structures were elucidated using MS analyses and extensive 2D‐homo and heteronuclear NMR data interpretations. Both compounds 1 and 2 could significantly shorten APTT and PT, and their procoagulant effect was comparable to that of positive drugs. At the same time, compound 2 had certain antioxidant activity (IC50 value of 2.25±0.05 μM in ABTS assay).

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202300448

Reference22 articles.

1. Anticoagulant activities of curcumin and its derivative

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