Affiliation:
1. School of Pharmaceutical Sciences Guizhou University Guiyang 550025 PR China
2. State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Guiyang 550014 PR China
3. Natural Products Research Center of Guizhou Province Guiyang 550014 PR China
Abstract
AbstractThree undescribed limonoids (1–3), named aglaians G–I, and one new natural product azedaralide (4), together with nine known analogues (5–13) were isolated from the branches and leaves of Aglaia lawii by RP C18 column, silica gel column, Sephadex LH‐20 column chromatography and preparative HPLC. The structures of the new compounds were elucidated by IR, HRESIMS, 1D, 2D NMR, electronic circular dichroism (ECD) calculations and X‐ray crystallography diffraction analysis. The results of bioassay showed that the compound 12 exhibited potential inhibitory activity against six human tumor cell lines (MDA‐MB‐231, MCF‐7, Ln‐cap, A549, HeLa and HepG‐2) with IC50 values as 8.0–18.6 μM.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Guizhou Province
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering