Affiliation:
1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of Pharmacy Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 P. R. China
2. Department of Pharmacy the Central Hospital of Wuhan Affiliated to Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 P. R. China
3. Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems and Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System School of Pharmacy Guangdong Pharmaceutical University Guangzhou 510006 P. R. China
Abstract
AbstractTwo pairs of new bisabolane‐type sesquiterpenoids, (+)‐aspersydowin A (7S) [(+)‐1], (−)‐aspersydowin A (7R) [(−)‐1], (+)‐aspersydowin B (7S,11S) [(+)‐2], (−)‐aspersydowin B (7R,11R) [(−)‐2], along with six known compounds (1–8) were isolated from the fungus Aspergillus sydowii. Compounds 1 and 2 are enantiomers resolved by the Chiralpak IC, using a hexane‐ propan‐2‐ol mobile phase. The structure of 1 and 2 with absolute configuration were assigned tentatively by 1D (1H, 13C, and DEPT) & 2D (HSQC, 1H–1H COSY, HMBC, and NOESY) NMR data analyses and ECD calculations. Compounds 1–8 were screened for the biological activities in vitro. The results showed that compounds 3, 4 and 8 exhibited immunosuppressive activities with IC50 values of 10.9, 17.6 and 13.4 μM, respectively.
Funder
National Natural Science Foundation of China
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering
Cited by
3 articles.
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