Affiliation:
1. Department of Chemical Engineering and Applied Chemistry College of Chemistry Jilin University 2699 Qianjin Street Changchun 130012 P. R. China
Abstract
AbstractAn efficient and green method for synthesizing 3‐methyl‐4‐(hetero) arylmethylene isoxazole‐5(4H)‐ones was developed using a recyclable and environmental–friendly catalyst, Na2S2O3, and 16 target compounds were successfully synthesized under the obtained optimal reaction condition. Using rifampicin as a positive control, the antibacterial activity of all synthesized compounds was tested by micro dilution method, among them, 3‐methyl‐4‐[(2,4‐dimethoxyphenyl) methylene]‐isoxazole‐5‐one (4 m) presented wonderful antimicrobial activity, which may contribute to the development of anti‐tuberculosis drugs.