Genome Mining and Molecular Networking Guided Isolation of Antimycin Analogs with Antifeedant Activities from the Deep‐Sea‐Derived Streptomyces sp. NA13

Author:

Bai Yan1,Ren Duo12,Li Fenglin1,Hu Jiangchun1,Pan Huaqi1ORCID

Affiliation:

1. Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China

2. School of Life Science and Biopharmaceutics Shenyang Pharmaceutical University Shenyang 110016 China

Abstract

AbstractPolyphagous insects could affect agricultural production, which leads to serious economic losses. Due to the negative effects of synthesized insecticides, finding eco‐friendly and new biopesticides is emergent. To develop natural origin insecticides, an integrative approach combining antifeedant activity screening, genome mining, and molecular networking has been applied to discover antifeedant secondary metabolites from Streptomyces sp. NA13, which leads to the isolation of a novel antimycin Q (1) and six known antimycin analogs (antimycins A1a, A2a, A3a, A4a, A7a, and N‐formylantimycic acid methyl ester, 27). Their structures were identified by high‐resolution mass spectrometry (HR‐MS) and nuclear magnetic resonance (NMR) spectroscopic. The absolute configuration of 1 was elucidated by the comparison of coupling constant, electronic circular dichroism (ECD) analysis, and NMR calculations. 16 exhibited different levels of antifeedant activities against Helicoverpa armigera, especially 1–4. At the same time, the antifeedant activity of antimycin was reported firstly.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

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