Affiliation:
1. Department of Chemistry College of Chemistry and Materials Science Jinan University Guangzhou 510632 P. R. China
Abstract
AbstractTwo new pairs of enantiomeric butenolides, (+)‐ and (−)‐suberiteslide A, (+)‐ and (−)‐subertieslide B had been obtained from the marine sponge Suberties sp. The structures with absolute configurations of these compounds were unequivocally determined by spectroscopic analyses and ECD (Electronic Circular Dichroism) method. It was the first separation of butenolides from the marine sponges of genus Suberites. Additionally, the anti‐inflammatory, antibacterial and cytotoxic activities of these compounds were evaluated. The result indicated that only (−)‐subertieslide B showed weak anti‐inflammatory activity with the IC50 value of 40.8 μM.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering