Affiliation:
1. Department of Analytical Chemistry and Standardization National Institute of Medicinal Materials (NIMM) Hanoi 11022 Vietnam
2. Department of Microbiology Immunology and Glycobiology Institute of Laboratory Medicine Lund University Lund Box 117 SE-221 00 Sweden
3. Thai Binh Medical University Thaibinh 410000 Vietnam
4. Hanoi University of Pharmacy Hanoi 11021 Vietnam
Abstract
AbstractFour new polyhydroxy pregnane glycosides, named volubilosides G−K (3, 5–7), along with three known secondary metabolites, dregeoside Da1 (1), dregeoside Ka1 (2), and volubiloside E (4) were isolated from the twigs and leaves of Dregea volubilis (DV). The chemical structures of these compounds (1–7) were elucidated using spectroscopic techniques (1D and 2D NMR and HR‐ESI‐MS analyses) and compared with those in the published literature. Compounds (1–7) were evaluated for cytotoxicity against eight cancer cell lines (MB49, K562, MKN‐7, HT29, A549, MCF‐7, MDA‐MB‐231, and HepG2), revealing varying levels of cytotoxic effects with IC50 values ranging from 4.29 to 21.05 μM. The results indicated that compounds 1–7 may serve as potential lead compounds for the discovery and development of novel anti‐cancer drugs.
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering