Affiliation:
1. Jilin Medical University, Jilin Jilin 132013 PR China
2. School of Life Sciences and Medicine Shandong University of Technology Zibo Shandong 255000 PR China
Abstract
AbstractIn this study, a series of rhodanine derivatives containing 5‐aryloxypyrazole moiety were identified as potential agents with anti‐inflammatory and anticancer properties. Most of the synthesized compounds demonstrated anti‐inflammatory and anticancer activity. Notably, compound 7 g (94.1 %) exhibited significant anti‐inflammatory activity compared with the reference drugs celecoxib (52.5 %) and hydrocortisone (79.4 %). Compound 7 g, at various concentrations, effectively inhibited nitric oxide (NO) production in a dose‐dependent manner. Western blot results showed that compound 7 g could prevents LPS‐induced expression of inflammatory mediators in macrophages. Enzyme‐linked immunosorbent assay (ELISA) assay suggested that 7 g is a promising compound capable of blocking the downstream signaling of COX‐2. In summary, these findings indicate that compound 7 g could be a promising candidate for further investigation.
Funder
Natural Science Foundation of Jilin Province
Education Department of Jilin Province
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering