Affiliation:
1. School of Pharmacy & State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University 550025 Guiyang P. R. China
2. State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 P. R. China
Abstract
AbstractThree new selaginellin derivatives, selaginpulvilins V‐X (1–3), together with seven known analogs (4–10) were isolated from whole plants of Selaginella pulvinata. Their structures were determined by extensive spectroscopic methods including 1D and 2D NMR, HR‐ESI‐MS and chemical derivatization method. Compound 1 represents a rare example of naturally occurring selaginellin with an alkynylphenol‐trimmed skeleton. Biological evaluation showed that compounds 2, 6 and 8 displayed moderate inhibition against α‐glucosidase with IC50 values of 3.71, 2.04 and 4.00 μM, respectively.
Funder
Natural Science Foundation of Yunnan Province
Guizhou Medical University
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering