Affiliation:
1. Centre for Drug Research Universiti Sains Malaysia 11800 USM Pulau Pinang Malaysia
2. School of Chemical Sciences Universiti Sains Malaysia 11800 USM Pulau Pinang Malaysia
3. Faculty of Marine Science and Environment Universiti Malaysia Terengganu Kuala Nerus 21030 Terengganu Malaysia
4. School of Biological Sciences Universiti Sains Malaysia 11800 USM Pulau Pinang Malaysia
5. Bioprocess Technology Division School of Industrial Technology Universiti Sains Malaysia Gelugor 11800 USM Penang Malaysia
6. Centre of Applied Science Studies Universiti Teknologi Mara 94300 UiTM Kuching Sarawak Malaysia
Abstract
AbstractThe genus Calophyllum from the family Calophyllaceae has been extensively investigated in the past due to its rich source of bioactive phenolics such as coumarins, chromanones, and xanthones. In this study, phytochemical investigation on the stem bark of Calophyllum havilandii has afforded a new 4‐propyldihydrocoumarin derivative, havilarin (1) together with calolongic acid (2), caloteysmannic acid (3), isocalolongic acid (4), euxanthone (5), and β‐sitosterol (6). The chemical structure of compound 1 was elucidated and established based on detailed spectroscopic techniques, including MS, IR, UV, 1D and 2D NMR. The results of anti‐bacillus study indicated that the chloroform extract showed promising activities with MIC value ranging between 0.5 to 1 μg/mL on selected bacillus strains. Besides, the plant extracts and compounds 1–4 were assessed for their cytotoxicity potential on HL‐7702 cell line. All the tested plant extracts and respective chemical constituents displayed non‐cytotoxic activity on HL‐7702 cell line.
Funder
Universiti Sains Malaysia