Terpenoids from Euphorbia helioscopia and Their Cytotoxic Activities against H1975 Cells

Author:

Zhang Xiong1,Peng Ming‐You1,Feng En‐Ming1,Li Qing‐Dan1,Chen Lu1,Yang Hu‐Cheng12,Guo Bing3,Liang Hong4,Di Ying‐Tong4,Tang Lei1,Yan Ying12ORCID

Affiliation:

1. State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D Guizhou Medical University Guiyang 550014 China

2. School of Medicine and Health Management Guizhou Medical University Guiyang 550025 China

3. Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University Guiyang China

4. State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany, Chinese Academy of Sciences Kunming 650201 Yunnan P. R. China

Abstract

AbstractThree previously undescribed diterpenoids, helioscopnoids A–C, and eight known compounds were isolated from the whole plants of Euphorbia helioscopia. Their structures were established by extensive analysis of spectra and data comparison with previous literatures. Among them, compound 4 was identified as 24,24‐dimethoxy‐25,26,27‐trinoreuphan‐3β‐ol with revised configurations of C‐13, C‐14, and C‐17 (13R*, 14R*, 17R*). Cytotoxicity assays revealed that all compounds exhibited varying levels of cytotoxicity against H1975 cells, with compound 9 displaying the most potent activity, as indicated by cell viability rates of 18.13 % and 20.76 % at concentrations of 20 μM and 5 μM, respectively. This study expands the understanding of E. helioscopia terpenoids’ structural diversity and biological activities, contributing to the exploration of potential therapeutic applications.

Funder

Science and Technology Program of Guizhou Province

Natural Science Foundation of Guizhou Province

Yunnan Provincial Science and Technology Department

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

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