Affiliation:
1. Department of Chemistry Faculty of Science Ain Shams University Abbassia 11566 Cairo Egypt
Abstract
AbstractN′‐[(4‐Chloro‐2‐oxo‐2H‐chromen‐3‐yl)methylene]‐2‐cyanoacetohydrazide (3) was synthesized in excellent yield from the condensation of 4‐Chloro‐2‐oxo‐2H‐chromene‐3‐carbaldehyde with cyanoacetohydrazide. Compound 3 was utilized as a building block to synthesize novel coumarin and heterocycle‐fused coumarin derivatives. The chemical structures of all the new coumarin compounds were identified by spectral analyses. Some of the new coumarins compounds were screened in human cancer cell lines (HEPG‐2, MCF‐7, HCT‐116 and PC‐3) to learn about their cytotoxic effects in addition to the study of their DNA damage and antioxidant activity. Three of these compounds exhibited remarkable antioxidant and anti‐proliferative activities. Moreover, they have the capability to protect DNA from damage induced by bleomycin. Molecular docking, DFT and molecular electrostatic potential studies were performed on the compounds in vitro.
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献