Pegylated Asparaginase‐Induced Liver Injury: A Case‐Based Review and Data From Pharmacovigilance

Author:

Vetro Calogero1ORCID,Duminuco Andrea2,Gozzo Lucia3,Maugeri Cinzia1,Parisi Marina1,Brancati Serena3,Longo Laura3,Vitale Daniela Cristina3,Romano Giovanni Luca4,Ciuni Roberto5,Mauro Elisa1,Fiumara Paolo Fabio1,Palumbo Giuseppe Alberto Maria126,Drago Filippo37,Di Raimondo Francesco15

Affiliation:

1. Haematology Unit Azienda Ospedaliero Universitaria Policlinico “G. Rodolico – S. Marco” Catania Italy

2. Postgraduate School of Hematology University of Catania Catania Italy

3. Clinical Pharmacology Unit/Regional Pharmacovigilance Centre Azienda Ospedaliero Universitaria Policlinico “G. Rodolico – S. Marco” Catania Italy

4. Department of Biomedical and Biotechnological Sciences University of Catania Catania Italy

5. Department of Chirurgia Generale e Specialità Medico‐Chirurgiche University of Catania Catania Italy

6. Department of Scienze Mediche Chirurgiche e Tecnologie Avanzate “G.F. Ingrassia” University of Catania Catania Italy

7. Centre for Research and Consultancy in HTA and Drug Regulatory Affairs (CERD), University of Catania Catania Italy

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference69 articles.

1. SwerdlowSH CampoE HarrisNL et al.WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues.France:Lyon;2008.

2. STUDIES ON THE MECHANISM OF TUMOR INHIBITION BY L-ASPARAGINASE

3. Incidence and management of asparaginase‐associated adverse events in patients with acute lymphoblastic leukemia;Earl M;Clin Adv Hematol Oncol,2009

4. Is asparaginase a critical component in the treatment of acute lymphoblastic leukemia?

5. A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403

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