Affiliation:
1. Department of Animal Nutrition, Faculty of Veterinary Medicine Firat University Elazig Turkey
2. Department of Animal Nutrition, Faculty of Veterinary Medicine Bingol University Bingol Turkey
3. Department of Biology, Faculty of Science Firat University Elazig Turkey
Abstract
AbstractMango ginger (MG) exhibits antioxidant, anti‐inflammatory, and antihyperglycemic effects; however, the exact mechanism of action of MG extract in relation to its antidiabetic properties remains unclear. To investigate the potential antidiabetic effect of MG extract, we used a high‐fat diet (HFD)/low‐dose streptozotocin (STZ)‐induced type 2 diabetic rat model. A total of 28 male Wistar rats were randomly divided into four groups: (i) Control, (ii) MG (50 mg/kg/day of MG extract), (iii) HFD + STZ (40 mg/kg i.p.), and (iv) HFD + STZ + MG. Following a 12‐week administration of MG extract, significant reductions were observed in serum glucose, insulin, free fatty acid, cholesterol, and triglyceride levels in diabetic rats (p < .0001 for all). MG extract supplementation led to an increase in the total antioxidant capacity of the serum and a decrease in malondialdehyde (MDA) levels in both the serum and liver (p < .0001). Furthermore, hepatocellular fat accumulation was partially attenuated in the HFD + STZ + MG group. Notably, MG extract inhibited glycogen synthase kinase‐3β (GSK‐3β) in the liver (p < .01) and downregulated Fyn expression, resulting in elevated nuclear factor erythroid 2–related factor 2 (Nrf2) activity in the HFD + STZ + MG group compared to the HFD + STZ group (p < .05). The increased activity of Nrf2 in the HFD + STZ + MG group likely promoted the upregulation of heme oxygenase 1 (HO‐1) in the liver (p < .0001). In conclusion, MG extract may exert antidiabetic effects by augmenting the antioxidant defense system through the regulation of GSK‐3β/Fyn/Nrf2 in a rat model of type 2 diabetes.
Funder
Firat University Scientific Research Projects Management Unit
Türkiye Bilimler Akademisi