PKC412 normalizes mutation-related keratin filament disruption and hepatic injury in mice by promoting keratin-myosin binding

Author:

Kwan Raymond12,Chen Lu13,Looi Koksun1,Tao Guo-Zhong4,Weerasinghe Sujith V.1,Snider Natasha T.1,Conti Mary Anne5,Adelstein Robert S.5,Xie Qing3,Omary M. Bishr12

Affiliation:

1. Departments of Molecular & Integrative Physiology and of Medicine; University of Michigan; Ann Arbor MI

2. VA Ann Arbor Healthcare System; Ann Arbor MI

3. Infectious Diseases Department; Ruijin Hospital, Shanghai Jiao Tong University Medical School; Shanghai People's Republic of China

4. Department of Surgery; Stanford University; Palo Alto CA

5. The Laboratory of Molecular Cardiology; National Heart, Lung, and Blood Institute, National Institutes of Health; Bethesda MD

Funder

National Institutes of Health

Publisher

Wiley

Subject

Hepatology

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