Association of fractal dimension and other retinal vascular network parameters with cognitive performance and neuroimaging biomarkers: The Multi‐Ethnic Study of Atherosclerosis (MESA)-Reference-Cited by-同舟云学术

Association of fractal dimension and other retinal vascular network parameters with cognitive performance and neuroimaging biomarkers: The Multi‐Ethnic Study of Atherosclerosis (MESA)

Published:2023-10-12 Issue: Volume: Page:
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Ong Sally S.¹^ORCID,Peavey Jeremy J.²,Hiatt Kevin D.³,Whitlow Christopher T.³,Sappington Rebecca M.¹⁴,Thompson Atalie C.¹,Lockhart Samuel N.²,Chen Haiying⁵,Craft Suzanne²,Rapp Stephen R.⁶,Fitzpatrick Annette L.⁷,Heckbert Susan R.⁷,Luchsinger José A.⁸,Klein Barbara E. K.⁹,Meuer Stacy M⁹,Cotch Mary Frances¹⁰,Wong Tien Y.¹¹¹²,Hughes Timothy M.²

Affiliation:

1. Department of Ophthalmology Wake Forest University School of Medicine Winston‐Salem North Carolina USA

2. Department of Internal Medicine Wake Forest University School of Medicine Winston‐Salem North Carolina USA

3. Department of Radiology Wake Forest University School of Medicine Winston‐Salem North Carolina USA

4. Department of Biochemistry Wake Forest School of Medicine Winston‐Salem North Carolina USA

5. Department of Psychiatry and Behavioral Medicine Wake Forest University School of Medicine Winston‐Salem North Carolina USA

6. Biostatistics and Data Science Wake Forest University School of Medicine Winston‐Salem North Carolina USA

7. Department of Epidemiology School of Public Health University of Washington Seattle Washington USA

8. Departments of Medicine and Epidemiology Columbia University Irving Medical Center New York New York USA

9. Department of Ophthalmology and Visual Sciences University of Wisconsin‐Madison Madison Wisconsin USA

10. National Eye Institute National Institute of Health Bethesda Maryland USA

11. Singapore Eye Research Institute Singapore National Eye Center Ophthalmology and Visual Sciences Academic Clinical Program Duke‐NUS Medical School Singapore

12. Tsinghua Medicine Tsinghua University Beijing China

Abstract

AbstractINTRODUCTIONRetinal vascular network changes may reflect the integrity of the cerebral microcirculation, and may be associated with cognitive impairment.METHODSAssociations of retinal vascular measures with cognitive function and MRI biomarkers were examined amongst Multi‐Ethnic Study of Atherosclerosis (MESA) participants in North Carolina who had gradable retinal photographs at Exams 2 (2002 to 2004, n = 313) and 5 (2010 to 2012, n = 306), and detailed cognitive testing and MRI at Exam 6 (2016 to 2018).RESULTSAfter adjustment for covariates and multiple comparisons, greater arteriolar fractal dimension (FD) at Exam 2 was associated with less isotropic free water of gray matter regions (β = −0.0005, SE = 0.0024, p = 0.01) at Exam 6, while greater arteriolar FD at Exam 5 was associated with greater gray matter cortical volume (in mm3, β = 5458, SE = 20.17, p = 0.04) at Exam 6.CONCLUSIONGreater arteriolar FD, reflecting greater complexity of the branching pattern of the retinal arteries, is associated with MRI biomarkers indicative of less neuroinflammation and neurodegeneration.

Funder

National Heart, Lung, and Blood Institute

National Center for Advancing Translational Sciences

National Institute on Aging

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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