Downregulation of the Wnt/β-catenin signaling pathway is involved in manganese-induced neurotoxicity in rat striatum and PC12 cells

Author:

Jiang Junkang1,Shi Shangshi1,Zhou Qiang2,Ma Xia1,Nie Xiaoke2,Yang Lingling3,Han Jingling1,Xu Guangfei2,Wan Chunhua2

Affiliation:

1. Department of Occupational Medicine and Environmental Toxicology; School of Public Health; Nantong University; Nantong Jiangsu China

2. Department of Nutrition and Food Hygiene; School of Public Health; Nantong University; Nantong Jiangsu China

3. Department of Emergency; Affiliated Hospital of Nantong University; Nantong Jiangsu China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience

Reference58 articles.

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2. Nutritional aspects of manganese homeostasis;Aschner;Mol Aspects Med,2005

3. Manganese: recent advances in understanding its transport and neurotoxicity;Aschner;Toxicol Appl Pharmacol,2007

4. Delta-catenin/NPRAP: a new member of the glycogen synthase kinase-3beta signaling complex that promotes beta-catenin turnover in neurons;Bareiss;J Neurosci Res,2010

5. Manganese-induced dopaminergic neurodegeneration: insights into mechanisms and genetics shared with Parkinson's disease;Benedetto;Chem Rev,2009

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