Affiliation:
1. Department of Anatomy Keio University School of Medicine Tokyo Japan
2. Department of Molecular Neurobiology Institute for Developmental Research Aichi Developmental Disability Center Kasugai Japan
Abstract
AbstractThe sophisticated function of the central nervous system (CNS) is largely supported by proper interactions between neural cells and blood vessels. Accumulating evidence has demonstrated that neurons and glial cells support the formation of blood vessels, which in turn, act as migratory scaffolds for these cell types. Neural progenitors are also involved in the regulation of blood vessel formation. This mutual interaction between neural cells and blood vessels is elegantly controlled by several chemokines, growth factors, extracellular matrix, and adhesion molecules such as integrins. Recent research has revealed that newly migrating cell types along blood vessels repel other preexisting migrating cell types, causing them to detach from the blood vessels. In this review, we discuss vascular formation and cell migration, particularly during development. Moreover, we discuss how the crosstalk between blood vessels and neurons and glial cells could be related to neurodevelopmental disorders.
Funder
Takeda Science Foundation
Japan Science and Technology Agency
Japan Society for the Promotion of Science
Subject
General Biochemistry, Genetics and Molecular Biology