Magnesium isoglycyrrhizinate promotes the activated hepatic stellate cells apoptosis via endoplasmic reticulum stress and ameliorates fibrogenesisin vitroandin vivo

Author:

Bian Mianli1234,Chen Xingran1234,Zhang Chenxi1234,Jin Huanhuan1234,Wang Feixia1234,Shao Jiangjuan1234,Chen Anping5,Zhang Feng1234,Zheng Shizhong1234ORCID

Affiliation:

1. Department of Pharmacology, School of Pharmacy; Nanjing University of Chinese Medicine; Nanjing Jiangsu China

2. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica; Nanjing University of Chinese Medicine; Nanjing Jiangsu China

3. Jiangsu Key Laboratory of Therapeutic Material of Chinese Medicine; Nanjing University of Chinese Medicine; Nanjing Jiangsu China

4. Jiangsu Key Laboratory for Functional Substance of Chinese Medicine; Nanjing University of Chinese Medicine; Nanjing Jiangsu China

5. Department of Pathology, School of Medicine; Saint Louis University; St Louis MO

Funder

National Natural Science Foundation of China

Youth Natural Science Foundation of Jiangsu Province

Publisher

Wiley

Subject

Clinical Biochemistry,Molecular Medicine,General Medicine,Biochemistry

Reference41 articles.

1. Fibrosis-a common pathway to organ injury and failure;Rockey;N. Engl. J. Med.,2015

2. Interactions between ECM and HSC cells in hepatic fibrosis;Li;Sheng Li Ke Xue Jin Zhan,2014

3. Integrins and heparan sulfate proteoglycans on hepatic stellate cells (HSC) are novel receptors for HSC-derived exosomes;Chen;FEBS Lett.,2016

4. HSC Fate Is Tethered to Mitochondria;Diebold;Cell Stem Cell,2016

5. Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells;Gonzalez-Fernandez;Biofactors,2017

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