Systematic Metabolic Profiling of Mice with Sleep‐Deprivation

Author:

Si Qingying1,Sun Wenxue23,Liang Benhui4,Chen Beibei23,Meng Junjun23,Xie Dadi1,Feng Lei5,Jiang Pei23ORCID

Affiliation:

1. Department of Endocrinology Tengzhou Central People's Hospital Tengzhou 277599 People's Republic of China

2. Translational Pharmaceutical Laboratory Jining First People's Hospital Shandong First Medical University Jining 272000 People's Republic of China

3. Institute of Translational Pharmacy Jining Medical Research Academy Jining 272000 People's Republic of China

4. Department of Cardiovascular Medicine Xiangya Hospital Central South University Changsha 410000 People's Republic of China

5. Department of Neurosurgery Jining First People's Hospital Shandong First Medical University Jining 272000 People's Republic of China

Abstract

AbstractAdequate sleep is essential for the biological maintenance of physical energy. Lack of sleep can affect thinking, lead to emotional anxiety, reduce immunity, and interfere with endocrine and metabolic processes, leading to disease. Previous studies have focused on long‐term sleep deprivation and the risk of cancer, heart disease, diabetes, and obesity. However, systematic metabolomics analyses of blood, heart, liver, spleen, kidney, brown adipose tissue, and fecal granules have not been performed. This study aims to systematically assess the metabolic changes in the target organs caused by sleep deprivation in vivo, to search for differential metabolites and the involved metabolic pathways, to further understand the impact of sleep deprivation on health, and to provide strong evidence for the need for early intervention.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Taishan Scholar Project of Shandong Province

China International Medical Foundation

Bethune Charitable Foundation

Publisher

Wiley

Subject

General Medicine

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