Macrophages – Controlling the Bifurcation Between Tumor Existence or Regression

Author:

Novobrantseva Tatiana1ORCID,Manfra Denise1,Nguyen Ani1,Feldman Igor1

Affiliation:

1. Research and Development Verseau Therapeutics Newton MA 02466 USA

Abstract

AbstractMacrophages are multifunctional cells that are employed by the tumor to further its growth and adaptation. While tumor‐associated macrophages (TAMs) have widely diverse phenotypes, tumors coevolve with the ones that can promote tumorigenesis. Functionally, TAMs/myeloid cells constitute the largest negative influence on the tumor microenvironment and need to be reprogrammed in order to enable successful anti‐tumor response in most tumors. It is predicted that successful TAM repolarization has the potential to become a staple of immuno‐oncology across most indications.

Publisher

Wiley

Subject

General Medicine

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