Affiliation:
1. Engineering Science and Mechanics Department Penn State University; University Park PA 16802 USA
2. The Huck Institutes of the Life Sciences Penn State University; University Park PA 16802 USA
3. Department of Biological Sciences Indian Institute of Science Education and Research Mohali Punjab 140306 India
4. Department of Chemistry Penn State University; University Park PA 16802 USA
5. Biomedical Engineering Department Penn State University; University Park PA 16802 USA
6. Materials Research Institute Penn State University; University Park PA 16802 USA
7. Cancer Institute Penn State University; University Park PA 16802 USA
Abstract
AbstractClinical lung transplantation has rapidly established itself as the gold standard of treatment for end‐stage lung diseases in a restricted group of patients since the first successful lung transplant occurred. Although significant progress has been made in lung transplantation, there are still numerous obstacles on the path to clinical success. The development of bioartificial lung grafts using patient‐derived cells may serve as an alternative treatment modality; however, challenges include developing appropriate scaffold materials, advanced culture strategies for lung‐specific multiple cell populations, and fully matured constructs to ensure increased transplant lifetime following implantation. This review highlights the development of tissue‐engineered tracheal and lung equivalents over the past two decades, key problems in lung transplantation in a clinical environment, the advancements made in scaffolds, bioprinting technologies, bioreactors, organoids, and organ‐on‐a‐chip technologies. The review aims to fill the lacuna in existing literature toward a holistic bioartificial lung tissue, including trachea, capillaries, airways, bifurcating bronchioles, lung disease models, and their clinical translation. Herein, the efforts are on bridging the application of lung tissue engineering methods in a clinical environment as it is thought that tissue engineering holds enormous promise for overcoming the challenges associated with the clinical translation of bioengineered human lung and its components.
Subject
General Biochemistry, Genetics and Molecular Biology,Biomedical Engineering,Biomaterials
Cited by
4 articles.
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