Leiodermatolide, a novel marine natural product, has potent cytotoxic and antimitotic activity against cancer cells, appears to affect microtubule dynamics, and exhibits antitumor activity

Author:

Guzmán Esther A.1,Xu Qunli2,Pitts Tara P.1,Mitsuhashi Kaoru Ogawa3,Baker Cheryl4,Linley Patricia A.1,Oestreicher Judy2,Tendyke Karen2,Winder Priscilla L.1,Suh Edward M.2,Wright Amy E.1

Affiliation:

1. Marine Biomedical and Biotechnology Research, Harbor Branch Oceanographic Institute at Florida Atlantic University Ft. Pierce; FL 34946

2. Eisai Research Institute of Boston Inc; Andover MA 01810-2441

3. Eisai Co, Ltd; Tsukuba-Shi Ibaraki 300-2635 Japan

4. Burnett School of Biomedical Sciences; University of Central Florida College of Medicine; Orlando FL 32827

Funder

National Cancer Institute

State of Florida Center of Excellence in Biomedical & Marine Biotechnology

NOAA Cooperative Institute for Ocean Exploration, Research and Technology

Health Resources & Services Administration Center for Sustainable Use of Marine Resources

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference31 articles.

1. Pancreatic Cancer Canada 2015 http://www.pancreaticcancercanada.ca/site/DocServer/facts_you_need_to_know.pdf?docID=741

2. American Cancer Society 2015 http://www.cancer.org/acs/groups/content/@editorial/documents/document/acspc-044552.pdf

3. Tubulin-interactive natural products as anticancer agents;Kingston;J Nat Prod,2009

4. Understanding and controlling the cell cycle with natural products;Hung;Chem Biol,1996

5. Microtubule-binding agents: a dynamic field of cancer therapeutics;Dumontet;Nat Rev Drug Discov,2010

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