Author:
Austin Marie-Paule,Mitchell Philip,Goodwin Guy M.
Abstract
BackgroundWhile depression is known to involve a disturbance of mood, movement and cognition, its associated cognitive deficits are frequently viewed as simple epiphenomena of the disorder.AimsTo review the status of cognitive deficits in depression and their putative neurobiological underpinnings.MethodSelective computerised review of the literature examining cognitive deficits in depression and their brain correlates.ResultsRecent studies report both mnemonic deficits and the presence of executive impairment – possibly selective for set-shifting tasks – in depression. Many studies suggest that these occur independent of age, depression severity and subtype, task ‘difficulty’, motivation and response bias: some persist upon clinical ‘recovery’.ConclusionsM nemonic and executive deficits do not appear to be epiphenomena of depressive disorder. A focus on the interactions between motivation, affect and cognitive function may allow greater understanding of the interplay between key aspects of the dorsal and ventral aspects of the prefrontal cortex in depression.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
925 articles.
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