Author:
Cahn W.,van Haren N. E. M.,Pol H. E. Hulshoff,Schnack H. G.,Caspers E.,Laponder D. A. J.,Kahn R. S.
Abstract
SummaryProgressive brain volume changes have been reported in first-episode schizophrenia, but their relationship to the disease process or to other factors remains unclear. We examined such changes in the first year of illness, and related them to 5-year outcome. Progressive brain volume changes, in particular of grey matter, during the first year of illness were found to be significantly associated with clinical and functional outcome 5 years after the first episode. These findings suggest that early dynamic brain volume changes are related to the disease process and predict the longer-term outcome of schizophrenia.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
117 articles.
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