Author:
Allen Paul,Amaro Edson,Fu Cynthia H. Y.,Williams Steven C. R.,Brammer Michael J.,Johns Louise C.,McGuire Philip K.
Abstract
BackgroundThe neurocognitive basis of auditory verbal hallucinations is
unclear.AimsTo investigate whether people with a history of such hallucinations would
misattribute their own speech as external and show differential
activation in brain areas implicated in hallucinations compared with
people without such hallucinations.MethodParticipants underwent functional magnetic resonance imaging (fMRI) while
listening to pre-recorded words. The source (self/non-self) and acoustic
quality (undistorted/distorted) were varied across trials. Participants
indicated whether the speech they heard was their own or that of another
person. Twenty people with schizophrenia (auditory verbal hallucinations
n=10, no hallucinations n=10) and
healthy controls (n=11) were tested.ResultsThe hallucinator group made more external misattributions and showed
altered activation in the superior temporal gyrus and anterior cingulate
compared with both other groups.ConclusionsThe misidentification of self-generated speech in patients with auditory
verbal hallucinations is associated with functional abnormalities in the
anterior cingulate and left temporal cortex. This may be related to
impairment in the explicit evaluation of ambiguous auditory verbal
stimuli.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
105 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献