Author:
Alemany Silvia,Arias Bárbara,Aguilera Mari,Villa Helena,Moya Jorge,Ibáñez Manuel I.,Vossen Helen,Gastó Cristobal,Ortet Generós,Fañanás Lourdes
Abstract
BackgroundThe well-established relationship between childhood adversity and
psychosis is likely to involve other factors such as genetic variants
that can help us to understand why not everyone exposed to adverse events
develops psychotic symptoms later in life.AimsWe investigated the influence of childhood abuse and neglect on positive
and negative psychotic-like experiences in adulthood and the potential
moderating effect of the BDNF-Val66Met polymorphism.MethodPsychotic-like experiences and childhood adversity were assessed in 533
individuals from the general population.ResultsChildhood abuse showed a strong independent effect on the positive
dimension of psychotic-like experiences (β = 0.16, s.e. = 0.05,
P = 0.002). Furthermore, this association was
moderated by the BDNF-Val66Met polymorphism (β = 0.27, s.e. = 0.10,
P = 0.004).ConclusionsIndividuals exposed to childhood abuse are more likely to report positive
psychotic-like experiences. Met carriers reported more
positive psychotic-like experiences when exposed to childhood abuse than
did individuals carrying the Val/Val genotype.
Therefore, the observed gene–environment interaction effect may be
partially responsible for individual variation in response to childhood
abuse.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
98 articles.
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