Author:
Szöke Andrei,Trandafir Anca,Dupont Marie-Estelle,Méary Alexandre,Schürhoff Franck,Leboyer Marion
Abstract
BackgroundA wide range of cognitive deficits have been demonstrated in schizophrenia, but their longitudinal course remains unclear.AimsTo bring together all the available information from longitudinal studies of cognitive performance in people with schizophrenia.MethodWe carried out a meta-analysis of 53 studies. Unlike previous reviewers, we included all studies (regardless of the type of medication), analysed each variable separately and compared results with data from controls.ResultsParticipants with schizophrenia showed a significant improvement in most cognitive tasks. The available data for controls showed, with one exception (the Stroop test), a similar or greater improvement. Performance in semantic verbal fluency remained stable in both individuals with schizophrenia and controls.ConclusionsParticipants with schizophrenia displayed improvement in most cognitive tasks, but practice was more likely than cognitive remediation to account for most of the improvements observed. Semantic verbal fluency may be the best candidate cognitive endophenotype.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Reference74 articles.
1. Letter and category fluency in schizophrenic patients: a meta-analysis
2. Longitudinal Wisconsin card sorting performance in schizophrenia patients in rehabilitation;Bryson;Appl Neuropsychol,2002
3. Stability of performance on neuropsychological tests in patients with schizophrenia
4. Quantifying heterogeneity in a meta-analysis
5. Longitudinal study of symptoms and cognitive function in chronic schizophrenia;Hughes;Schizophr Res,2002
Cited by
274 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献