Author:
Beucke Jan C.,Sepulcre Jorge,Eldaief Mark C.,Sebold Miriam,Kathmann Norbert,Kaufmann Christian
Abstract
BackgroundAlthough neurobiological models of obsessive–compulsive disorder (OCD)
traditionally emphasise the central role of corticostriatal brain
regions, studies of default mode network integrity have garnered
increasing interest, but have produced conflicting results.AimsTo resolve these discrepant findings by examining the integrity of
default mode network subsystems in OCD.MethodComparison of seed-based resting-state functional connectivity of 11
default mode network components between 46 patients with OCD and 46
controls using functional magnetic resonance imaging.ResultsSignificantly reduced connectivity within the dorsal medial prefrontal
cortex self subsystem was identified in the OCD group, and remained
significant after controlling for medication status and life-time history
of affective disorders. Further, greater connectivity between the self
subsystem and salience and attention networks was observed.ConclusionsResults indicate that people with OCD show abnormalities in a neural
system previously associated with self-referential processing in healthy
individuals, and suggest the need for examination of dynamic interactions
between this default mode network subsystem and other large-scale
networks in this disorder.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
85 articles.
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