Author:
Hirvikoski Tatja,Mittendorfer-Rutz Ellenor,Boman Marcus,Larsson Henrik,Lichtenstein Paul,Bölte Sven
Abstract
BackgroundMortality has been suggested to be increased in autism spectrum disorder
(ASD).AimsTo examine both all-cause and cause-specific mortality in ASD, as well as
investigate moderating role of gender and intellectual ability.MethodOdds ratios (ORs) were calculated for a population-based cohort of ASD
probands (n = 27 122, diagnosed between 1987 and 2009)
compared with gender-, age- and county of residence-matched controls
(n = 2 672 185).ResultsDuring the observed period, 24 358 (0.91%) individuals in the general
population died, whereas the corresponding figure for individuals with
ASD was 706 (2.60%; OR = 2.56; 95% CI 2.38–2.76). Cause-specific analyses
showed elevated mortality in ASD for almost all analysed diagnostic
categories. Mortality and patterns for cause-specific mortality were
partly moderated by gender and general intellectual ability.ConclusionsPremature mortality was markedly increased in ASD owing to a multitude of
medical conditions.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Cited by
652 articles.
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