Author:
Puri B. K.,Davey N. J.,Ellaway P. H.,Lewis S. W.
Abstract
BackgroundIn this first investigation of motor function in schizophrenia using transcranial magnetic stimulation (TMS), the general hypothesis tested was that this methodology could be used to investigate the disruption of corticospinal inhibitory processes suggested by cognitive and psychophysiological paradigms.MethodNine drug-free DSM–IV schizophrenic patients were compared with nine age- and sex-matched normal subjects. Electromyographic (EMG) recordings were made from the thenar muscles of the dominant hand during sustained, weak voluntary contraction. TMS over a particular threshold applied to the motor cortex would elicit a compound motor evoked potential (cMEP) followed by a period of suppression of EMG.ResultsThe latency of cMEPs following TMS was significantly shorter in the schizophrenic patients. The two groups did not differ significantly with respect to mean latency of suppression of EMG activity, or stimulus thresholds for either cMEPs or EMG suppression.ConclusionThese findings could be the result of a relative lack of corticospinal inhibition of motor responses; a change in the site of TMS activation; or an abnormality of peripheral nervous function in schizophrenia. Drug effects were unlikely since seven of the patients were drug-naïve.
Publisher
Royal College of Psychiatrists
Subject
Psychiatry and Mental health
Reference20 articles.
1. Facilitation of word recognition by semantic priming in schizophrenia.
2. Recording an identified pyramidal volley evoked by transcranial magnetic stimulation in a conscious macaque monkey
3. Direct and indirect activation of corticospinal neurones by electrical and magnetic stimulation in the anaesthetized macaque monkey;Edgley;Journal of Physiology,1992
4. Suppression of voluntary motor activity revealed using transcranial magnetic stimulation of the motor cortex in man.
5. Spatial inaccuracy of remembered saccades induced by transcranial magnetic stimulation over the dorsolateral prefrontal cortex in man;Shaunak;Journal of Physiology,1995
Cited by
62 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献