Frequencies of Chromosome Aberrations are Lower in Splenic Lymphocytes from Mice Continuously Exposed to Very Low-Dose-Rate Gamma Rays Compared with Non-Irradiated Control Mice

Author:

Kohda Atsushi1,Toyokawa Takuo2,Umino Tomoyuki2,Ayabe Yoshiko3,Tanaka Ignacia Braga1,Komura Jun-ichiro1

Affiliation:

1. aDepartment of Radiobiology, Institute for Environmental Sciences (IES), 2-121 Hacchazawa, Takahoko, Rokkasho, Kamikita, Aomori 039-3213, Japan

2. bTohoku Nuclear Co., Ltd., 2-41-14 Higashi Okamisawa, Misawa, Aomori 033-0024, Japan

3. cTohoku Research Center, Forestry and Forest Product Research Institute, 92-25 Nabeyashiki, Shimo-Kuriyagawa, Morioka, Iwate 020-0123, Japan

Abstract

Chromosome aberrations have been one of the most sensitive and reliable biomarkers of exposure to ionizing radiation. Using the multiplex fluorescence in situ hybridization (M-FISH) technique, we compared the changes, over time, in the frequencies of translocations and of dicentric chromosomes in the splenic lymphocytes from specific pathogen-free (SPF) C3H/HeN female mice continuously exposed to 0.05 mGy/day (18.25 mGy/year) gamma rays for 125 to 700 days (total accumulated doses: 6.25–35 mGy) compare with age-matched non-irradiated controls. Results show that the frequencies of translocations and of dicentric chromosomes increased significantly over time in both irradiated and non-irradiated control mice, and that the frequencies were significantly lower, not higher, in the irradiated mice, which differs from our previous reports of increased chromosome aberration frequencies at higher radiation dose rates of 1 mGy/day and 20 mGy/day. These results will be useful when considering the radiation risk at very low-dose rates comparable to regulatory dose limits.

Publisher

Radiation Research Society

Subject

Radiology, Nuclear Medicine and imaging,Radiation,Biophysics

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