New thrombopoietin receptor agonist: avatrombopag
Author:
Affiliation:
1. 大阪府赤十字血液センター
2. 大阪大学大学院医学系研究科血液・腫瘍内科学
Publisher
Japanese Society on Thrombosis and Hemostasis
Link
https://www.jstage.jst.go.jp/article/jjsth/35/4/35_2024_JJTH_35_4_468-472/_pdf
Reference21 articles.
1. 1) Fukushima-Shintani M, Suzuki K, Iwatsuki Y, et al.: AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist. Eur J Haematol 82: 247–254, 2009.
2. 2) Yassin MA, Al-Rasheed M, Al-Khaboori M, et al.: Thrombopoietin-receptor agonists for adult patients with immune thrombocytopenia: A narrative review and an approach for managing patients fasting intermittently. Front Cardiovasc Med 10: 1260487, 2023.
3. 3) Nomoto M, Pastino G, Rege B, et al.: Pharmacokinetics, pharmacodynamics, pharmacogenomics, safety, and tolerability of avatrombopag in healthy Japanese and white subjects. Clin Pharmacol Drug Dev 7: 188–195, 2018.
4. 4) Kuter DJ: The structure, function, and clinical use of the thrombopoietin receptor agonist avatrombopag. Blood Rev 53: 100909, 2022.
5. 5) Kuter DJ, Allen LF: Avatrombopag, an oral thrombopoietin receptor agonist: Results of two double-blind, dose-rising, placebo-controlled Phase 1 studies. Br J Haematol 183: 466–478, 2018.
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