MMP9 −1562 C/T POLİMORFİZMİ, TÜRK TİP 2 DİABETES MELLİTUS HASTALARINDA ARTMIŞ DİYABETİK RETİNOPATİ RİSKİ İLE İLİŞKİLİDİR

Abstract

Objective Type 2 diabetes mellitus (T2DM) and diabetic retinopathy (DR) development is affected by genetic factors. Matrix metalloproteinases (MMPs) are involved in many cellular processes, such as remodeling of extracellular matrix proteins and angiogenesis. In this study, we investigated the relationship between MMP9 −1562 C/T (rs3918242) polymorphism and the development of T2DM and DR in Turkish population. Material and Method A total of 510 participants, involving 168 T2DM cases with DR, 168 T2DM cases without DR, and 174 controls, were included in the study. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was carried out to identify genotypes. Results The CT, CT+TT genotypes and the T allele of the MMP9 −1562 C/T polymorphism were associated with increased risk of DR (p=0.001). On the other hand, no relationship was found between the development of T2DM and this polymorphism. In addition, CT (p=0.010) and CT+TT (p=0.015) genotype frequencies were found to be higher in proliferative diabetic retinopathy (PDR) cases compared to nonproliferative diabetic retinopathy (NPDR) cases, but after regression analysis, only insulin use (p=0.003) was found to be associated with the development of PDR. Conclusion Our data show that the MMP9 −1562 C/T polymorphism is associated with the development of DR in Turkish T2DM patients, but no significant relationship was found between this polymorphism and the severity of DR and the development of T2DM.