Affiliation:
1. KÜTAHYA SAĞLIK BİLİMLERİ ÜNİVERSİTESİ EVLİYA ÇELEBİ EĞİTİM VE ARAŞTIRMA HASTANESİ
2. SÜLEYMAN DEMİREL ÜNİVERSİTESİ, TIP FAKÜLTESİ
Abstract
Objective
Olanzapine has adverse effects on sexual dysfunction.
There are a limited number of studies showing that it
also causes structural changes in the reproductive
system. This study aimed to examine the effects of
L-Carnitine on testicular damage caused by Olanzapine
in terms of histopathological, sperm parameters, and
biochemical aspects.
Material and Method
A total of 48 adult Sprague-Dawley male rats were
used in our study. Rats were divided into 6 groups,
8 rats in each group: the Control group (C), 200 mg/
kg L-Carnitine administered group (LC), 2 mg/kg low
dose Olanzapine administered group (LOZN), 2 mg/kg
Olanzapine, and 200 mg/kg L-Carnitine administered
group (LOZN+LC), 4 mg/kg Olanzapine administered
group (HOZN), 4 mg/kg Olanzapine and 200 mg/
kg L-Carnitine administered group (HOZN+LC).
Testicular tissues were used for the determination of
MDA, IL-1B, IL-6, TAS, TOS levels, and histological
evaluation.
Results
In the groups receiving Olanzapine, a decrease in
sperm count, an increase in MDA, IL-1β, TOS values,
and dose-dependent histopathological changes in
testicular tissue were observed. Histopathological
changes were found at a lower rate in the Olanzapine
and L-Carnitine administered groups compared to the
Olanzapine-only groups.
Conclusion
It was concluded that the degenerative histological
findings in the testicular structure observed in the
high-dose Olanzapine administered groups might be
caused by the oxidative stress induced by Olanzapine
in the testicular tissue. L-Carnitine, on the other hand,
was thought to be effective in reducing testicular
degeneration by reducing oxidative damage.
Funder
This study was supported by the Süleyman Demirel University Scientific Research Project Office
Publisher
Medical Journal of Suleyman Demirel University