Affiliation:
1. SULEYMAN DEMIREL UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES, DEPARTMENT OF HISTOLOGY AND EMBRYOLOGY
2. MEHMET AKIF ERSOY UNIVERSITY, BUCAK HEALTH ACADEMY
Abstract
Objective
We aimed to investigate the effects of flaxseed,
which is widely used due to its healing effects, on the
kidney tissue when the daily recommended dose is
exceeded.
Material and Methods
We divided the male Wistar Albino rats into four
groups of eight, namely the control, OD-1 (1.4 mg/
kg/d), OD-2 (2.8 mg/kg/d), and OD-3 (5.6 mg/kg/d)
groups. Ground flaxseed was administered to each
overdose group by oral gavage for 7 days. At the
end of the experiment, blood and kidney samples
were collected. Blood samples were centrifuged and
serum was separated for renal function analyses.
The half of the kidney samples were stored at -20
°C until biochemical analyses and we fixed the
remaining tissues with 10% buffered formalin for
histopathological analysis.
Results
Serum urea and BUN levels were significantly
increased in all overdose groups compared to the
control group (for all p˂0.05). TAS levels significantly
decreased in the OD-3 group compared to the control
(p=0.044). There was an increase renal TOS levels
in all overdose groups compared to the control
and also, OSI level of the OD-3 group significantly
increased compared to the control (p=0.016). While
histopathological changes were not observed in OD-1
and OD-2 groups compared to the control group,
there were non-significant histopathological changes
in OD-3 group.
Conclusion
It was concluded that the use of flaxseed above the
recommended daily dose can pose a threat to kidney
tissue. So, while being used for its benefit, in order not
to be exposed to its toxic effects, overuse and longterm
use should be avoided.
Publisher
Medical Journal of Suleyman Demirel University