Effect of Beta-casomorphin-7 on Renal Function and Immunity in Aging Mice

Abstract

Background: Most studies have shown that Beta-Casomorphin-7 (BCM-7) has many physiological functions, this study aims to investigate the effects of BCM-7 on renal function and immunity in naturally aging mice and to reveal the effects of BCM-7 on health and provide more theoretical reference for inflammatory aging.Methods: All mice were weighed weekly and the organ indexes were calculated, Paraffin sections were prepared for kidney histopathological examination with conventional Haematoxylin and Eosin (HE) staining, renal function indexes and cytokines were main measured by ELISA and biochemical colorimetry.Result: The weight of each group increased during gastric perfusion and the higher the intervention concentration, the lower the weight gain rate. The renal index was not affected by BCM-7, but the spleen index was significantly decreased by medium-dose BCM-7. There were inflammatory cell infiltration and other renal lesions in the aging control group and intervention group. A medium dose of BCM-7 can significantly reduce Cystatin C (Cys-C) content in aging mice, the content of Adrenocorticotropic hormone (ACTH) in aged mice decreased with the increase of BCM-7 intervention dose. BCM-7 and aging caused cytokine imbalance in mice.