Affiliation:
1. Department of Clinical Oncology, Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong Hong Kong
2. Department of Clinical Oncology, Shenzhen Key Laboratory for Cancer Metastasis and Personalized Therapy The University of Hong Kong‐Shenzhen Hospital Shenzhen China
3. Laboratory for Synthetic Chemistry and Chemical Biology Hong Kong (SAR) China
Abstract
AbstractMost mature B cells can be divided into four subtypes based on the expression of the surface markers IgD and CD27: IgD+CD27− naïve B cells, IgD+CD27+ unswitched memory B cells, IgD−CD27+ switched memory B cells, and IgD−CD27− double‐negative (DN) B cells. Despite their small population size in normal peripheral blood, DN B cells play integral roles in various diseases. For example, they generate autoimmunity in autoimmune conditions, while these cells may generate both autoimmune and antipathogenic responses in COVID‐19, or act in a purely antipathogenic capacity in malaria. Recently, DN B cells have been identified in nasopharyngeal carcinoma and non‐small‐cell lung cancers, where they may play an immunosuppressive role. The distinct functions that DN B cells play in different diseases suggest that they are a heterogeneous B‐cell population. Therefore, further study of the mechanisms underlying the involvement of DN B cells in these diseases is essential for understanding their pathogenesis and the development of therapeutic strategies. Further research is thus warranted to characterize the DN B‐cell population in detail.
Funder
Health and Medical Research Fund
Innovation and Technology Fund
Publisher
Springer Science and Business Media LLC
Cited by
4 articles.
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