Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19

Author:

Theobald Sebastian J12,Simonis Alexander12ORCID,Georgomanolis Theodoros3ORCID,Kreer Christoph4ORCID,Zehner Matthias4,Eisfeld Hannah S12,Albert Marie‐Christine56,Chhen Jason12,Motameny Susanne3ORCID,Erger Florian37,Fischer Julia128ORCID,Malin Jakob J12ORCID,Gräb Jessica12,Winter Sandra12,Pouikli Andromachi9,David Friederike3ORCID,Böll Boris1,Koehler Philipp125,Vanshylla Kanika4,Gruell Henning4ORCID,Suárez Isabelle18,Hallek Michael1,Fätkenheuer Gerd18,Jung Norma18,Cornely Oliver A1258,Lehmann Clara128,Tessarz Peter59ORCID,Altmüller Janine3,Nürnberg Peter23,Kashkar Hamid56,Klein Florian48,Koch Manuel1011,Rybniker Jan128ORCID

Affiliation:

1. Department I of Internal Medicine Faculty of Medicine and University Hospital of Cologne University of Cologne Cologne Germany

2. Faculty of Medicine and University Hospital of Cologne Center for Molecular Medicine Cologne (CMMC) University of Cologne Cologne Germany

3. Faculty of Medicine and University Hospital of Cologne Cologne Center for Genomics (CCG) University of Cologne Cologne Germany

4. Laboratory of Experimental Immunology Institute of Virology Faculty of Medicine and University Hospital of Cologne University of Cologne Cologne Germany

5. Excellence Cluster on Cellular Stress Responses in Aging‐Associated Diseases (CECAD) University of Cologne Cologne Germany

6. Institute for Medical Microbiology, Immunology and Hygiene (IMMIH) University of Cologne Cologne Germany

7. Faculty of Medicine Institute of Human Genetics University Hospital Cologne Cologne Germany

8. German Center for Infection Research (DZIF), Partner Site Bonn‐Cologne Cologne Germany

9. Max Planck Research Group “Chromatin and Ageing” Max Planck Institute for Biology of Ageing Cologne Germany

10. Medical Faculty Institute for Dental Research and Oral Musculoskeletal Biology University of Cologne Cologne Germany

11. Medical Faculty Center for Biochemistry University of Cologne Cologne Germany

Funder

Deutsches Zentrum für Infektionsforschung

Deutsche Forschungsgemeinschaft

Publisher

EMBO

Subject

Molecular Medicine

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