A new ALK inhibitor overcomes resistance to first‐ and second‐generation inhibitors in NSCLC

Author:

Lu Yue1,Fan Zhenzhen2,Zhu Su‐Jie345,Huang Xiaoxing1,Zhuang Zhongji1,Li Yunzhan1,Deng Zhou1,Gao Lei2,Hong Xuehui6,Zhang Ting1,Li Li1,Sun Xihuan1,Huang Wei1ORCID,Zhang Jingfang1,Liu Yan1,Zhang Baoding1,Jiang Jie1,Gui Fu1ORCID,Wang Zheng1ORCID,Li Qiyuan7,Song Siyang1,Huang Xin8,Wu Qiao1,Chen Lanfen1,Zhou Dawang1,Zhang Jianming9ORCID,Yun Cai‐Hong34ORCID,Chen Liang2ORCID,Deng Xianming1ORCID

Affiliation:

1. State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling Network School of Life Sciences Xiamen University Xiamen China

2. Institute of Life and Health Engineering Jinan University Guangzhou China

3. Department of Biochemistry and Biophysics Institute of Systems Biomedicine Peking University Health Science Center Beijing China

4. Beijing Key Laboratory of Tumor Systems Biology School of Basic Medical Sciences Peking University Health Science Center Beijing China

5. Institute for Translational Medicine College of Medicine Qingdao University Qingdao China

6. Department of Gastrointestinal Surgery Affiliated Zhongshan Hospital of Xiamen University Xiamen China

7. National Institute for Data Science in Health and Medicine School of Medicine Xiamen University Xiamen China

8. Division of Drug Discovery Hongyun Biotech Co., Ltd. Nanjing China

9. National Research Center for Translational Medicine Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China

Funder

National Key Research and Development Program of China

Fundamental Research Funds for the Central Universities

Xiamen Municipal Bureau of Science and Technology

National Natural Science Foundation of China

Publisher

EMBO

Subject

Molecular Medicine

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