The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma

Author:

Lin Shengchen1,Huang Chongbiao2,Sun Jianwei134,Bollt Oana5,Wang Xiuchao12,Martine Eric1,Kang Jiaxin14,Taylor Matthew D5,Fang Bin6,Singh Pankaj K7,Koomen John6,Hao Jihui2ORCID,Yang Shengyu18ORCID

Affiliation:

1. Department of Cellular and Molecular Physiology The Pennsylvania State University College of Medicine Hershey PA USA

2. Key Laboratory of Cancer Prevention and Therapy Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Tianjin China

3. State Key Laboratory of Natural Resource Conservation and Utilization in Yunnan and Center for Life Science School of Life Sciences Yunnan University Kunming China

4. South China Agricultural University Guangzhou China

5. Department of Surgery The Pennsylvania State University College of Medicine Hershey PA USA

6. Department of Molecular Oncology Proteomics & Metabolomics Core H. Lee Moffitt Cancer Center Tampa FL USA

7. Department of Pathology and Microbiology Eppley Institute for Research in Cancer and Allied Diseases University of Nebraska Medical Center Omaha NE USA

8. Department of Tumor Biology H. Lee Moffitt Cancer Center Tampa FL USA

Funder

National Institutes of Health

U.S. Department of Defense

Elsa U. Pardee Foundation

Penn State Hershey Cancer Institute

Publisher

EMBO

Subject

Molecular Medicine

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