Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity-Reference-Cited by-同舟云学术

Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity

Published:2022-09-07 Issue:10 Volume:14 Page:
ISSN:1757-4676
Container-title:EMBO Molecular Medicine
language:en
Short-container-title:EMBO Mol Med

Author:

Güner Gökhan¹²,Aßfalg Marlene¹²,Zhao Kai³,Dreyer Tobias⁴,Lahiri Shibojyoti⁵,Lo Yun⁶,Slivinschi Bianca Ionela¹²,Imhof Axel⁵^ORCID,Jocher Georg¹²^ORCID,Strohm Laura⁷^ORCID,Behrends Christian⁷^ORCID,Langosch Dieter⁸^ORCID,Bronger Holger⁴⁹^ORCID,Nimsky Christopher³^ORCID,Bartsch Jörg W³^ORCID,Riddell Stanley R⁶¹⁰,Steiner Harald¹¹¹^ORCID,Lichtenthaler Stefan F¹²¹²^ORCID

Affiliation:

1. German Center for Neurodegenerative Diseases (DZNE) Munich Germany

2. Neuroproteomics, School of Medicine, Klinikum rechts der Isar Technical University of Munich Munich Germany

3. Department of Neurosurgery Philipps University Marburg Marburg Germany

4. Department of Gynecology and Obstetrics, School of Medicine, Klinikum rechts der Isar Technical University of Munich Munich Germany

5. Protein Analysis Unit, Faculty of Medicine Biomedical Center, LMU Martinsried Germany

6. Immunotherapy Integrated Research Center Fred Hutchinson Cancer Research Center Seattle WA USA

7. Munich Cluster for Systems Neurology (SyNergy), Medical Faculty LMU Munich Germany

8. Technical University of Munich Freising Germany

9. German Cancer Consortium (DKTK), partner site Munich and German Cancer Research Center (DKFZ) Heidelberg Germany

10. Department of Medicine University of Washington Seattle WA USA

11. Division of Metabolic Biochemistry, Faculty of Medicine, Biomedical Center (BMC) LMU Munich Germany

12. Munich Cluster for Systems Neurology (SyNergy) Munich Germany

Funder

Bundesministerium für Bildung und Forschung

Deutsche Forschungsgemeinschaft

National Institutes of Health

Publisher

EMBO

Subject

Molecular Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/emmm.202216084

Reference83 articles.

1. Signalling pathways of the TNF superfamily: a double-edged sword

2. Therapeutic efficacy and safety of a human fusion construct targeting the TWEAK receptor Fn14 and containing a modified granzyme B

3. An atomic structure of human γ-secretase

4. Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain

5. TWEAK-Independent Fn14 Self-Association and NF-κB Activation Is Mediated by the C-Terminal Region of the Fn14 Cytoplasmic Domain

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