Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism-Reference-Cited by-同舟云学术

Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism

Published:2021-03-05 Issue:4 Volume:13 Page:
ISSN:1757-4676
Container-title:EMBO Molecular Medicine
language:en
Short-container-title:EMBO Mol Med

Author:

Hartleben Goetz¹²³,Schorpp Kenji⁴,Kwon Yun¹²³,Betz Barbara¹²³^ORCID,Tsokanos Foivos‐Filippos¹²³,Dantes Zahra⁵,Schäfer Arlett⁵,Rothenaigner Ina⁴,Monroy Kuhn José Manuel⁶,Morigny Pauline¹²³,Mehr Lisa¹²³,Lin Sean⁴^ORCID,Seitz Susanne¹²³,Tokarz Janina⁷,Artati Anna⁷,Adamsky Jerzy³⁷⁸⁹,Plettenburg Oliver¹⁰¹¹,Lutter Dominik⁶,Irmler Martin¹²,Beckers Johannes³¹²¹³,Reichert Maximilian⁵¹⁴¹⁵,Hadian Kamyar⁴,Zeigerer Anja¹²³,Herzig Stephan¹²³¹⁶^ORCID,Berriel Diaz Mauricio¹²³^ORCID

Affiliation:

1. Institute for Diabetes and Cancer Helmholtz Center Munich Neuherberg Germany

2. Joint Heidelberg‐IDC Translational Diabetes Program Heidelberg University Hospital Heidelberg Germany

3. German Center for Diabetes Research (DZD) Neuherberg Germany

4. Assay Development and Screening Platform Institute of Molecular Toxicology and Pharmacology Helmholtz Zentrum München Neuherberg Germany

5. Klinik und Poliklinik für Innere Medizin II Klinikum rechts der Isar Technical University of Munich Munich Germany

6. Institute for Diabetes and Obesity Neuherberg Germany

7. Research Unit Molecular Endocrinology and Metabolism Helmholtz Center Munich Neuherberg Germany

8. Lehrstuhl für Experimentelle Genetik Technische Universtität München Freising‐Weihenstephan Germany

9. Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Singapore City Singapore

10. Institute of Medicinal Chemistry Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) Neuherberg Germany

11. Institute of Organic Chemistry Center of Biomolecular Drug Research (BMWZ) Leibniz University Hannover Hannover Germany

12. Institute of Experimental Genetics Helmholtz Zentrum München GmbH Neuherberg Germany

13. Technische Universität München Chair of Experimental Genetics Freising Germany

14. Center for Protein Assemblies (CPA) Technische Universität München Garching Germany

15. German Cancer Consortium (DKTK) Munich Germany

16. Chair Molecular Metabolic Control Technical University Munich Munich Germany

Funder

Deutsche Forschungsgemeinschaft

Deutsche Krebshilfe

Publisher

EMBO

Subject

Molecular Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/emmm.202012461

Reference44 articles.

1. Effect of mitochondrial uncouplers niclosamide ethanolamine (NEN) and oxyclozanide on hepatic metastasis of colon cancer

2. Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer

3. SUMO pathway inhibition targets an aggressive pancreatic cancer subtype

4. Organoid Models of Human and Mouse Ductal Pancreatic Cancer

5. A framework for oligonucleotide microarray preprocessing

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