Specific RNA interactions promote TDP‐43 multivalent phase separation and maintain liquid properties
Author:
Affiliation:
1. Edward Doisy Department of Biochemistry and Molecular Biology Saint Louis University St. Louis MO USA
2. Department of Neurology Washington University School of Medicine St. Louis MO USA
Funder
National Institute of Neurological Disorders and Stroke
U.S. Department of Defense
Publisher
EMBO
Subject
Genetics,Molecular Biology,Biochemistry
Link
https://onlinelibrary.wiley.com/doi/pdf/10.15252/embr.202153632
Reference65 articles.
1. Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation
2. Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations
3. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
4. TDP-43 regulates its mRNA levels through a negative feedback loop
5. TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression
Cited by 42 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. RNA and the RNA-binding protein FUS act in concert to prevent TDP-43 spatial segregation;Journal of Biological Chemistry;2024-02
2. Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates;2024-01-23
3. Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD;Molecular Neurodegeneration;2024-01-22
4. More than a bystander: RNAs specify multifaceted behaviors of liquid‐liquid phase‐separated biomolecular condensates;BioEssays;2024-01-04
5. KIF1C, an RNA transporting kinesin-3, undergoes liquid-liquid phase separation through its C-terminal disordered domain;2023-10-23
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3