A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

Author:

Simon Matthew1ORCID,Yang Jiping2ORCID,Gigas Jonathan1,Earley Eric J3ORCID,Hillpot Eric1,Zhang Lei4,Zagorulya Maria1,Tombline Greg1,Gilbert Michael5,Yuen Samantha L4,Pope Alexis2,Van Meter Michael1,Emmrich Stephan1ORCID,Firsanov Denis1,Athreya Advait1ORCID,Biashad Seyed Ali1ORCID,Han Jeehae6,Ryu Seungjin6ORCID,Tare Archana6,Zhu Yizhou6ORCID,Hudgins Adam6ORCID,Atzmon Gil67,Barzilai Nir6,Wolfe Aaron8ORCID,Moody Kelsey8,Garcia Benjamin A5,Thomas David D4ORCID,Robbins Paul D4,Vijg Jan6ORCID,Seluanov Andrei1ORCID,Suh Yousin2ORCID,Gorbunova Vera1ORCID

Affiliation:

1. Department of Biology University of Rochester Rochester NY USA

2. Department of Obstetrics and Gynecology Columbia University New York NY USA

3. Biostatistics and Epidemiology RTI International Durham NC USA

4. Department of Biochemistry, Molecular Biology and Biophysics and Institute on the Biology of Aging and Metabolism University of Minnesota Minneapolis MN USA

5. Department of Biochemistry and Biophysics, Perelman School of Medicine University of Pennsylvania Philadelphia PA USA

6. Department of Genetics Albert Einstein College of Medicine Bronx NY USA

7. Department of Biology, Faculty of Natural Sciences University of Haifa Haifa Israel

8. Ichor Therapeutics Lafayette NY USA

Funder

National Institutes of Health

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

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