Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

Author:

Anderson Rhys12,Lagnado Anthony12,Maggiorani Damien3ORCID,Walaszczyk Anna4,Dookun Emily24,Chapman James12,Birch Jodie12,Salmonowicz Hanna12,Ogrodnik Mikolaj12,Jurk Diana125,Proctor Carole12,Correia‐Melo Clara12,Victorelli Stella12,Fielder Edward12,Berlinguer‐Palmini Rolando6ORCID,Owens Andrew4,Greaves Laura C7,Kolsky Kathy L8,Parini Angelo3,Douin‐Echinard Victorine3,LeBrasseur Nathan K8,Arthur Helen M4,Tual‐Chalot Simon4,Schafer Marissa J8,Roos Carolyn M8,Miller Jordan D8,Robertson Neil9,Mann Jelena10,Adams Peter D911,Tchkonia Tamara8,Kirkland James L8,Mialet‐Perez Jeanne3ORCID,Richardson Gavin D4ORCID,Passos João F125ORCID

Affiliation:

1. Ageing Research Laboratories Institute for Ageing Newcastle University Newcastle upon Tyne UK

2. Institute for Cell and Molecular Biosciences Newcastle University Newcastle upon Tyne UK

3. INSERM Institute of metabolic and cardiovascular diseases University of Toulouse Toulouse France

4. Cardiovascular Research Centre Institute for Genetic Medicine Newcastle University Newcastle upon Tyne UK

5. Department of Physiology and Biomedical Engineering Mayo Clinic Rochester MN USA

6. The Bio‐Imaging Unit Newcastle University Newcastle upon Tyne UK

7. Wellcome Trust Centre for Mitochondrial Research Centre for Ageing and Vitality Newcastle University Newcastle upon Tyne UK

8. Robert and Arlene Kogod Center on Aging Mayo Clinic Rochester MN USA

9. Institute of Cancer Sciences CR‐UK Beatson Institute University of Glasgow Glasgow UK

10. Institute of Cellular Medicine Newcastle University Newcastle upon Tyne UK

11. Sanford Burnham Prebys Medical Discovery Institute La Jolla CA USA

Funder

Biotechnology and Biological Sciences Research Council

British Heart Foundation

Foundation for the National Institutes of Health

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

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