Cytosolic RNA:DNA hybrids activate the cGAS –STING axis-Reference-Cited by-同舟云学术

Cytosolic RNA:DNA hybrids activate the cGAS –STING axis

Published:2014-11-25 Issue:24 Volume:33 Page:2937-2946
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:EMBO J

Author:

Mankan Arun K¹,Schmidt Tobias¹,Chauhan Dhruv¹,Goldeck Marion²,Höning Klara¹,Gaidt Moritz¹,Kubarenko Andrew V¹,Andreeva Liudmila³,Hopfner Karl‐Peter³,Hornung Veit¹

Affiliation:

1. Institute of Molecular Medicine University Hospital University of Bonn Bonn Germany

2. Institute of Clinical Chemistry and Clinical Pharmacology University Hospital University of Bonn Bonn Germany

3. Department of Biochemistry and Gene Center Ludwig‐Maximilians‐University Munich Germany

Funder

German Research Foundation

European Research Council

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.201488726

Reference39 articles.

1. cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

2. Nucleic acid driven sterile inflammation

3. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

4. TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner

5. Nucleic Acid Recognition by the Innate Immune System

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