SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells

Author:

Lukassen Soeren12ORCID,Chua Robert Lorenz12,Trefzer Timo12,Kahn Nicolas C34,Schneider Marc A45,Muley Thomas45,Winter Hauke46,Meister Michael45,Veith Carmen7,Boots Agnes W8,Hennig Bianca P12,Kreuter Michael34ORCID,Conrad Christian12ORCID,Eils Roland129ORCID

Affiliation:

1. Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Berlin Germany

2. Center for Digital Health; Berlin Institute of Health (BIH); Berlin Germany

3. Department of Pneumology and Respiratory Critical Care Medicine; Center for interstitial and rare lung diseases; Thoraxklinik, Heidelberg University Hospital; Heidelberg Germany

4. Translational Lung Research Center Heidelberg (TLRC); Member of the German Center for Lung Research (DZL); Heidelberg Germany

5. Translational Research Unit; Thoraxklinik, Heidelberg University Hospital; Heidelberg Germany

6. Department of Thoracic Surgery; Thoraxklinik, Heidelberg University Hospital; Heidelberg Germany

7. Division of Redox Regulation; German Cancer Research Center (DKFZ) ; Heidelberg Germany

8. Faculty of Health, Medicine and Life Sciences; Department of Pharmacology and Toxicology; NUTRIM School of Nutrition; Translational Research and Metabolism; Maastricht University; Maastricht the Netherlands

9. Health Data Science Unit; Heidelberg University Hospital and BioQuant; Heidelberg Germany

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Reference60 articles.

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2. Controlling the false discovery rate: a practical and powerful approach to multiple testing;Benjamini;J Roy Stat Soc,1995

3. Epidemiology and transmission of COVID-19 in shenzhen china: analysis of 391 cases and 1,286 of their close contacts;Bi;medRxiv,2020

4. The novel coronavirus - a snapshot of current knowledge;Brussow;Microb Biotechnol,2020

5. Coronavirus cell entry occurs through the endo-/lysosomal pathway in a proteolysis-dependent manner;Burkard;PLoS Pathog,2014

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