A covalently bound inhibitor triggers EZH 2 degradation through CHIP ‐mediated ubiquitination-Reference-Cited by-同舟云学术

A covalently bound inhibitor triggers EZH 2 degradation through CHIP ‐mediated ubiquitination

Published:2017-03-20 Issue:9 Volume:36 Page:1243-1260
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:EMBO J

Author:

Wang Xu¹²,Cao Wei¹²,Zhang Jianjun¹²,Yan Ming¹²,Xu Qin¹²,Wu Xiangbing¹²,Wan Lixin³,Zhang Zhiyuan¹²,Zhang Chenping¹²,Qin Xing¹²,Xiao Meng¹²,Ye Dongxia²,Liu Yuyang²,Han Zeguang⁴,Wang Shaomeng⁵,Mao Li¹⁶,Wei Wenyi³,Chen Wantao¹²^ORCID

Affiliation:

1. Faculty of Oral and Maxillofacial Surgery Department of Oral and Maxillofacial Head & Neck Oncology Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China

2. Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology Shanghai China

3. Department of Pathology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA

4. Shanghai Center for Systems Biomedicine Shanghai Jiao Tong University Shanghai China

5. Comprehensive Cancer Center Departments of Internal Medicine Pharmacology and Medicinal Chemistry University of Michigan Ann Arbor MI USA

6. Department of Oncology and Diagnostic Sciences University of Maryland School of Dentistry Baltimore MD USA

Funder

National Natural Science Foundation of China

National Institutes of Health

Science and Technology Commission of Shanghai Municipality

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.201694058

Reference67 articles.

1. A High-Throughput Assay to Identify Modifiers of Premature Chromosome Condensation

2. Comprehensive side-effect profile of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: long-term safety analysis of the ATAC trial

3. ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids

4. Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors

5. Molecular Signals of Epigenetic States

Cited by 63 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Regulation of EZH2 protein stability: new mechanisms, roles in tumorigenesis, and roads to the clinic;eBioMedicine;2024-02

2. Design, synthesis, and biological evaluation of gambogenic acid derivatives: Unraveling their anti-cancer effects by inducing pyroptosis;Bioorganic Chemistry;2024-02

3. Induced protein degradation for therapeutics: past, present, and future;Journal of Clinical Investigation;2024-01-02

4. Small molecules targeting selected histone methyltransferases (HMTs) for cancer treatment: Current progress and novel strategies;European Journal of Medicinal Chemistry;2024-01

5. Discovery of dihydropyridinone derivative as a covalent EZH2 degrader;European Journal of Medicinal Chemistry;2023-12