Chemogenetic profiling reveals PP2A‐independent cytotoxicity of proposed PP2A activators iHAP1 and DT‐061-Reference-Cited by-同舟云学术

Chemogenetic profiling reveals PP2A‐independent cytotoxicity of proposed PP2A activators iHAP1 and DT‐061

Published:2022-06-13 Issue:14 Volume:41 Page:
ISSN:0261-4189
Container-title:The EMBO Journal
language:en
Short-container-title:The EMBO Journal

Author:

Vit Gianmatteo¹^ORCID,Duro Joana¹^ORCID,Rajendraprasad Girish²^ORCID,Hertz Emil P T¹,Holland Lya Katrine Kauffeldt³,Weisser Melanie Bianca¹,McEwan Brennan C⁴⁵,Lopez‐Mendez Blanca¹^ORCID,Sotelo‐Parrilla Paula⁶^ORCID,Jeyaprakash A Arockia⁶^ORCID,Montoya Guillermo¹,Mailand Niels¹^ORCID,Maeda Kenji³,Kettenbach Arminja⁴^ORCID,Barisic Marin²⁷^ORCID,Nilsson Jakob¹^ORCID

Affiliation:

1. Novo Nordisk Foundation Center for Protein Research Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark

2. Cell Division and Cytoskeleton Danish Cancer Society Research Center Copenhagen Denmark

3. Cell Death and Metabolism Unit Center for Autophagy, Recycling and Disease (CARD) Danish Cancer Society Research Center (DCRC) Copenhagen Denmark

4. Department of Biochemistry and Cell Biology Geisel School of Medicine at Dartmouth College Hanover NH USA

5. Norris Cotton Cancer Center Lebanon NH USA

6. Wellcome Trust Center for Cell Biology University of Edinburgh Edinburgh UK

7. Department of Cellular and Molecular Medicine Faculty of Health Sciences University of Copenhagen Copenhagen Denmark

Funder

Novo Nordisk Fonden

Danish Cancer Society Research Center

Danmarks Frie Forskningsfond

Lundbeckfonden

Wellcome Trust

Publisher

EMBO

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.2022110611

Reference68 articles.

1. PHENIX: a comprehensive Python-based system for macromolecular structure solution

2. Spindly/CCDC99 Is Required for Efficient Chromosome Congression and Mitotic Checkpoint Regulation

3. Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p

4. Purification of brain tubulin through two cycles of polymerization–depolymerization in a high-molarity buffer

5. Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. PP2A complex disruptor SET prompts widespread hypertranscription of growth-essential genes in the pancreatic cancer cells;Science Advances;2024-01-26

2. Comprehensive review of CRISPR-based gene editing: mechanisms, challenges, and applications in cancer therapy;Molecular Cancer;2024-01-09

3. Altering phosphorylation in cancer through PP2A modifiers;Cancer Cell International;2024-01-06

4. A strategy to disentangle direct and indirect effects on (de)phosphorylation by chemical modulators of the phosphatase PP1 in complex cellular contexts;Chemical Science;2024

5. Small-Molecule Activation of Protein Phosphatase 2A Counters Bleomycin-Induced Fibrosis in Mice;ACS Pharmacology & Translational Science;2023-10-17